Nanopore sequencing analysis

Pathogen identified.
45 minutes.

Nanolix runs adaptive basecalling directly on nanopore flow cell output — no cloud dependency, no latency tax — designed for clinical laboratory validation at the point of care.

<45 min
Pathogen ID from raw reads — point-of-care time frame
12–15%
Raw nanopore error rate handled natively by adaptive basecalling
Zero
Cloud dependency at point of care — complete local execution

Cloud callers weren't built for the bedside

Standard basecalling pipelines assume you have time. Research labs tolerate 2-4 hour cloud roundtrips because the clinical answer can wait. Hospital ICUs cannot.

The 12–15% raw error rate in nanopore sequencing is manageable in research — you run longer, average more reads. In a clinical setting, every minute of additional sequencing time is a minute before the infectious disease physician can act on your result.

Consensus-only callers aren't optimized for the error profile of clinical isolates. They were trained on reference genomes, not the diverse pathogen populations you'll see in a hospital microbiology laboratory.

Nanolix re-implements the basecalling stack from first principles: on-device, real-time, adaptive — with a pathogen-specific model library trained on clinical isolates.

From raw signal to clinical answer

Three stages. All local. Under 45 minutes.

01
Ingest

Raw ionic current signal from Oxford Nanopore flow cell output is read in real-time as reads stream from the sequencer. No batch collection, no waiting for run completion.

02
Adapt

On-device adaptive basecalling corrects the 12–15% raw error rate without cloud roundtrip. Context-aware model conditions on preceding bases and signal context to reduce systematic errors at homopolymer runs and modified-base-rich sequences.

03
Identify

Pathogen ID, AMR gene detection, and a confidence score delivered sub-45-minutes. Results formatted for direct output to your LIS via HL7 v2 or FHIR. No cloud. No data leaves your facility.

Designed for the pathogens your lab faces most

Current identification panel — continuously updated. All organisms identified from Oxford Nanopore flow cell output data.

GRAM+
Staphylococcus aureus
MRSA variant included
GRAM−
Klebsiella pneumoniae
KPC + NDM AMR detection
GRAM−
Escherichia coli
ESBL strain coverage
GRAM−
Pseudomonas aeruginosa
HAI priority pathogen
FUNGAL
Candida auris
Multidrug-resistant yeast
VIRAL
Influenza A/B
Respiratory panel
VIRAL
RSV A/B
Respiratory panel
GRAM+
C. difficile
Toxin gene detection
View full organism library

Internal validation data

LDT-compatible architecture, designed for hospital laboratory validation workflows.

Concordance with culture
On request
Internal validation data available to qualified laboratory partners under NDA.
AMR gene detection
On request
Validation data available for mecA, blaKPC, blaNDM, vanA/B panel on request.
Time-to-result
< 45 minutes
Demonstrated across internal test panel from raw signal to pathogen call.

Validation data available to qualified laboratory partners. Nanolix is software — clinical validation is the responsibility of the implementing laboratory under LDT regulatory frameworks.

Runs where your sequencer runs

Complete local execution architecture. No cloud in the critical path.

Nanopore Flow Cell Output FAST5 / POD5 NANOLIX EDGE Adaptive basecalling Pathogen alignment AMR gene detection Local GPU/NPU inference PATHOGEN RESULT ID + AMR + Confidence < 45 minutes LIS / HL7 v2 ORU message EHR / FHIR R4 DiagnosticReport LIMS / Webhook JSON payload Cloud sync (optional only)

Cloud node shown as optional reporting sync only — not in the critical analysis path.

Connects to your clinical workflow

Standard outputs for LIS, EHR, and LIMS environments. Zero proprietary lock-in.

Oxford Nanopore flow cell output
HL7 FHIR R4
HL7 v2 LIS messaging
CSV / JSON export
LIMS webhook
View integration details

Ready to bring sequencing to point-of-care?

Request access for your laboratory's evaluation. No per-run fees — one site license, unlimited runs.